Gluten Blast

Larazotide Acetate is an 8–amino acid peptide that progressed to Phase 3 clinical trials for celiac disease. It works to keep tight junctions supporting normal, selective permeability rather than excessive leakiness. By modulating zonulin signalling, it helps reduce inappropriate antigen passage across the intestinal barrier without interfering with nutrient absorption.

PEA (Palmitoylethanolamide) is an endogenous fatty acid amide and endocannabinoid that down-modulates mast cell activation — a key driver of intestinal inflammation and barrier destabilisation. By calming inflammatory signalling, PEA supports epithelial resilience, mucosal balance, and immune regulation within the gut environment.

The gliadin (gluten) molecule can increase intestinal permeability in both celiac and non-celiac individuals by stimulating zonulin release. This formula is designed to support tight junction regulation and reduce exaggerated permeability responses — helping prevent excessive gliadin translocation across the gut barrier. This blend supports intelligent permeability control — allowing tight junctions to do their very important job of gatekeeping properly.